Exactly what the title says. 

I try to base mine on jetBlue, but it gets to a point where I have to start flying internationally. 

If you are a scamline, charge max price for the worst products. If you are looking for quality, have zero charge on the highest quality products.

A320 family base fee?

Soo... I am operating A319LRs on my CLT > LHR route but operating 787-8s on my SAT > LHR route. I found that the route operated by the A319LR has a much better reputation (it has a pretty high frequency) but the route operated the 787-8s have a higher profit. Should I operate a mix of both types to maintain a high profit and a reputation, or should I just ditch the narrowbodies and start flying more widebodies and put the narrowbodies on more frequent transcontinental routes? (my reputation is hovering around a 96 right now, but I want to bring it up to a 100)

I really never took a loan before, but stick to smaller airports, build up your wealth, and squash your competition. 

As for leased aircraft, it wasn't until my valuation reached 10B did I start buying my loaned aircraft. Typically buying 1-2 new aircraft when you have 1B in the bank is a good idea.

They seem very similar, anyone mind pointing out the differences, apart from "one is made by Airbus and the other by Boeing"?

Dayum, wonder how much you are paying those flight attendants. 

Its maiden flight was January 31st, 2018, so we will have to see when the first delivery is. However, it could be a 757 replacement-wannabe for the late games in the 2010's.

All they want to do is to make you bankrupt.

Try flights to Houston, which is very close and has 2 major airports. If all else fails, Austin is also in the region.

Maybe 787, maybe large A330, maybe 757-300.

787, A330, or even 757

Boeing 737 family

If they were to build an airport in the Vatican, it might as well be a RC port. Even still, that might be too big.

A320/B734/8 on routes with more demand, A319/B733/7 on routes with less demand.

Charlotte > San Diego.

When we were splitting the demand between three airlines, and we kept economy prices at $1750...
 

Then some kid comes in with 58x 737-800 flights a week, with no IFE nor IFS but the ticket is $500...

Yeah, it just has a way of tearing apart a market.

Thing is... all of the airlines that I observed doing this have under 500M value and under 100 aircraft.

Generally I replace them when my 10-year leases expire, although some replace them at the 5 year mark.

So you see a juicy route with 2500 demand and you want to get a share of the candy, right? Undercutting other airlines on such routes might make you money for a week or so in-game, but once other airlines find out that you lowered your ticket prices to $500 when they are charging $750, they will also lower their fares. You will be tempted to lower your prices again to $300, only to find 100% passenger load in all classes but you are losing money. You want to raise it back, but it is too late, as the other airlines on the route also lowered their prices to $300. Now nobody is making a profit, and passengers are not willing to pay $750 for the route again because one scamline is flying the route for $250.

Beware of having a 90% max reputation.

747 BBJ because according to your personal info, "i am a failure", I thought, "why the hell not stick her in a 747 business jet?"

And so it happened.

10. When you are around 5-7 days from the end of a month, STOP YOUR SPENDING AND JUST SAVE UP UNTIL THE MONTH END. Fuel costs, maintenance, and aircraft/gate leasing all come within a very short span of time, and having a cushion is always better than going into the negatives.

Okay - so this might sound like it contradicts nearly EVERYTHING on this post, but you can try it, and it worked for me (at least for now)

1. Get 757s if available. You can use them on nearly every type of route. Use 1 first class seat to every 7 business class seats, and 3-4 first class seats for a 757 should do. Fill up first class and business class, and when checking economy class, do 10 less seats than max capacity. This gives you good reputation.

2. Join the largest alliance possible. If there are two alliances that are very close, take a look at the two and choose the one with the most airlines on top 20.

3. Small airports. Google maps. Wikipedia.

4. SPAM your 757s on transcontinental routes from small airports in large cities.

5. Add "feeder" flights that are about 1-2 hours from your "main" airports (i.e. if you do Burbank-Hollywood > Charlotte, do flights from Burbank to El Paso and Charlotte to Durham or Savannah.)

6. IFE and IFS: as generous as you can be IF AND ONLY IF YOU ARE JOINING A "legacy" GAME. YOU WILL NEVER CATCH UP TO AN AIRLINE WORTH BILLIONS/TRILLIONS OF DOLLARS, BUT REPUTATION WILL ALLOW YOU TO COMPETE ON A DIFFERENT PLAYING FIELD. Disregard if you are in a "new" world.

7. Set up 3 "hubs" (but don't make them hubs) on the East coast (small airports near large cities). Set up 3 "hubs" on the West Coast (small airports). Connect them with transcontinental flights. 

8. Once you start hitting 50M DOP or so, you can start being more aggressive. Don't forget that larger airlines are making 500M+ DOP, so you cannot be too aggressive.

9. Little tip regarding A330-300 and A340-300: A330-300 is more expensive, burns more fuel, has less range, but the same seating and speed as the A340-300. A340-300 has a longer turnaround time (75 v.s. 90 minutes).