Hypothetical,
Spam IFS/IFE,
Business/Economy only,
Super massive/busy route,
Limited flights
Jack up the prices
Would that do the trick?
You'd want a route as close to the max range (2890 miles)
I know that the Concorde can make a profit with those settings (I've done it before), especially since its turn time has been reduced (previously it was an unreasonable 2 hours!), but is the Tu-144's fuel flow too much to overcome? I honestly don't know, but I think you'd need to schedule it on just about every single route with limited flights that you could jack up prices on that's near to the maximum range. It may be possible if the plane is only based at certain hubs with good geographic positioning.
I'll do it.
Good luck!