With the situation getting nastier by day around the US3 and ME3. The US Government and the Trump administration are forced to pick sides with Either Boeing or US3 in regards with Open Skies agreements.
In one hand, the growth of ME3 is beneficial for Boeing who sell them tons of aircraft, ranging from B737 to the famous B777. And of course, the ME3 is the back bone of B777X program. 72% of B777x backlogs come from ME3 alone. With possible heavy restrictions on Open Skies agreements, there would be big retaliations from ME3 because they can't easily access or grow into the US markets, hence they need to cut back on certain capacity which resulted on how they needed less aircraft.
With this possible outcome, do you think Airbus could launch A350-2000? Because I've heard they cancel this project because many of their prospective customers goes with B777X instead (Singapore airlines, Cathay Pacific, ME3, or Lufthansa). Hence they didn't want to waste money on the aircraft that nobody gonna buy.