Depends. If its profits your after, then 3 high seated 747s. But operating 3 weekly flights won't give you a good route reputation whereas operating 10 A320s will increase it significantly. Also depends on route length and cost of airport gate, and if you have various routes of 700 pax demand into it, then if you have various 10 A320s operating that route you're gonna use more gates (thus increasing prices). But if you whack 3 747s then you'll probably be good to go on one gate.
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