The best B767-200ER & B767-300ER replacements?

I am operating the B767-200ER with a 42/222 configuration and the B767-300ER with a 42/283 configuration. What is the best aircraft for replacement for both types?

777-200 or 767-400

A330 and Dreamliner work too. 

If you're talking about Spring Air, then it's 2015.

Seeing as you already have the A330-200 (and it's in a much denser configuration), you'd need something the same size/capacity of the existing model, not an upgrade. In that case, I'd steer you towards the 787-8, which has roughly the same capacity as the 767-300ER.

Unfortunately, I cannot recommend you a replacement for the 767-200ER (it's somewhat of a niche aircraft, with no real replacement that has the same range). You can only really go up or down in capacity and range, unfortunately. Closest in physical size going up would be the 787-8, but it would be too much aircraft for some routes. Closest in size going down would be the A321neo, although it would have fewer seats and less range. 

I am operating the B767-200ER with a 42/222 configuration and the B767-300ER with a 42/283 configuration. What is the best aircraft for replacement for both types?

i think you will find that the A330-200/-300 are probably the best options for replacing the 767-200ER/300ER, even though you might have a bit more capacity.

And as N664US said, probably in the later game, the 787-8/-9 are great options to up to along with the A350-900.

If you're talking about Spring Air, then it's 2015.

Seeing as you already have the A330-200 (and it's in a much denser configuration), you'd need something the same size/capacity of the existing model, not an upgrade. In that case, I'd steer you towards the 787-8, which has roughly the same capacity as the 767-300ER.

Unfortunately, I cannot recommend you a replacement for the 767-200ER (it's somewhat of a niche aircraft, with no real replacement that has the same range). You can only really go up or down in capacity and range, unfortunately. Closest in physical size going up would be the 787-8, but it would be too much aircraft for some routes. Closest in size going down would be the A321neo, although it would have fewer seats and less range.