The airline industry is unstable as we know, but random events put the business in perall so, if somehing signifficant happened one year in the real world that changed avaiation make it happen when a game world hits that date. Also weathers issues should be happening like an airport sends the airline a message warning them of heavy snow and airports cant function in snow so the airport can tempereally close an flights from that aiport will stop making profit until it opens again. If a crash could happen then you lose an aircrft or it need maintancing and theirs a fine for the airline. Fake charitys can be set up and the airline can donate money to the charity and recieve a reputation increase!
These are just my ideas.