Alitalia-Linee Aeree Italiane (The old Alitalia that went bankrupt in 2009, not to be confused with the current Alitalia that may go bankrupt soon??? )
For me are the DC-8 variants -20, -30 and -40 are worse, the standard VC-10, all russian planes except the TU-204 and the SSJ, the A340-500 and i´ve made also bad experiences with the 707-400 and the Trident 1C.
And don´t forget the Caravelle except the 1 and the 12 because the fact that except the 12 all JT8D Variant aren´t in the game.
Some of the most profitable routes my airlines have done have been flown with DC-8s and DC6s in all 1st and business class layouts from JFK to ZHR/GVA, but this was at the start of a new world, so you could charge sky-high prices to achieve this.
I also once had an airline based in Cuba with a fleet of Russian planes like the Il-62 and somehow made a profit (this was way back in like 2011)