There is no best option for the 220-240 seat market. Every available option has shortfalls:
Boeing 757-200:Terrible Fuel efficiency. Great range
Airbus A321-200: Decent fuel efficiency. Vastly inferior range
Airbus A321neo: Decent fuel efficiency. Inferior range
Is suppose the 757-200, in spite of it's fuel efficiency-issues, will solve a lot of headaches for a lot of players when they're sorting out their routes. That range is very, very handy.