I love the CRJ1000EL for short distance shuttle routes where I want 70x or more weekly frequencies.
For narrowbodies, my other favourites are A319,320,321 & CS100,300.
For widebodies, I really like the 787-8 & the 767-400ER. The 777-300 is amazing for profits, but runway length requirements limit the airports you can serve with it. I also really liked the A330-300 but I noticed that the purchase/lease price has been dramatically increased recently, so I'll likely use the A340-300 in game despite it being far worse in real life.
For turboprobs, I really like Q300,Q400 & ATR-42-600 & ATR-72-600.