All the fuel flows in this game are fundamentally wrong.
The game's fuel flow model is based on (1) total takeoff thrust and (2) takeoff thrust specific fuel consumption (SFC).
This is totally wrong for multiple reasons:
-The model assumes, basically, that the engines are at max thrust throughout the whole flight. In reality this is far from true - cruise thrust is a fraction of takeoff thrust, on the order of 25%.
-The model uses takeoff SFC for the whole flight. The real important figure is cruise SFC, which is always higher due to several reasons, the biggest of which is thrust lapse due to forward speed (an engine kicking out exhaust at 600mph produces more thrust at break release than when the plane is travelling at 500mph)
-The model takes no account of the aerodynamic/structural considerations that would dictate how much cruise thrust, and thus how much fuel, is needed. In cruise, thrust=drag. Drag is determined primarily by weight, wingspan, and wetted area of the plane.
...taking all these into consideration would be a bit complicated. However, the model could use an average fuel flow figure from publicly available data like Airport Compatibility Manuals provided by the manufacturers, and then adjust for mission range (+/- a few percent depending on whether flying very short or very long distances).
The bottom line of all these discrepancies is that planes in this game burn significantly more fuel than they do in the real world. The assumption of maximum thrust dominates over the assumption of lower takeoff SFC.
One more thing - folks assume that quads burn more than twins. That's a decent assumption for the kinds of actual twins and quads that we have, but the quads that we have are all old (747/A340) or else relatively poor designs (A380).
Folks have noticed, for example, that quads are more efficient in this game than you'd expect. That's because the model is based on takeoff thrust: a quad needs less takeoff thrust than a twin because the total amount of thrust is related to takeoff requirements when one engine dies. Obviously this impacts a twin more than a quad, so quads will have less total takeoff power than a similarly-sized twin (all else being equal). Thus quads can have smaller engines, which helps fuel efficiency in a lot of ways that should be obvious. The A340-300, for example, was pretty close to the 777-200ER in real life fuel burn, despite being an older design. The A340NG is just a bad idea - too much stretch of a narrow fuselage and therefore too heavy a plane.